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Q. How can researchers solve contradictions in this compound's β-arrestin recruitment knowledge throughout experimental circumstances?
This substance continues to be analyzed on mice and its toxicological and pharmacological knowledge are incomplete.
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The foremost solutions formed from these reactions depend on the particular situations and reagents utilized. One example is, oxidation of this compound can lead to the formation of assorted oxidized derivatives, even though reduction can yield minimized types of the compound
. These interactions are hypothesized to stabilize receptor conformations favoring Gαi/o coupling around β-arrestin recruitment
This material is a research material and is meant for study in specially Geared up laboratories.
In head-to-head trials, this compound outperformed both morphine and oxycodone concerning analgesic efficacy when eliciting fewer Unwanted side effects. This positions it as a promising applicant for pain management strategies, notably in populations in danger for opioid dependence
Mice treated with this compound exhibited no significant withdrawal signs and symptoms in comparison to These treated with morphine. This implies a decrease prospective for dependence and withdrawal problems associated with extensive-expression opioid therapy
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Substitution: Nucleophilic substitution reactions can be executed employing reagents like sodium methoxide or potassium tert-butoxide.
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